SANCHEZ OLEA, ROBERTO

Publicaciones ORCID

2025

Characterization of the carboxy‐terminal domain of the GPN‐loop GTPase Npa3 reveals an intrinsically disordered region and phosphorylation‐dependent regulation in the absence of BUD27 The FEBS Journal

Proposal of Chemical Inhibitors That Compete with the Binding of RNA Polymerase II Subunits to Essential GTPases GPN Npa3 and Gpn1 ACS Omega

2022

Synthetic negative genome screen of the GPN-loop GTPase NPA3 in Saccharomyces cerevisiae Current Genetics

2019

FRET‐based analysis and molecular modeling of the human GPN-loop GTPases 1 and 3 heterodimer unvelis a dominant-negative protein complex The FEBS Journal

Gpn3 Is Essential for Cell Proliferation of Breast Cancer Cells Independent of Their Malignancy Degree Technology in Cancer Research & Treatment

2017

Gpn3 is polyubiquitinated on lysine 216 and degraded by the proteasome in the cell nucleus in a Gpn1-inhibitable manner FEBS Letters

The Gpn3 Q279* cancer-associated mutant inhibits Gpn1 nuclear export and is deficient in RNA polymerase II nuclear targeting FEBS Letters

Human Gpn1 purified from bacteria binds guanine nucleotides and hydrolyzes GTP as a protein dimer stabilized by its C-terminal tail Protein Expression and Purification

Npa3/ Sc Gpn1 carboxy-terminal tail is dispensable for cell viability and RNA polymerase II nuclear targeting but critical for microtubule stability and function Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

2014

Gpn1 and Gpn3 associate tightly and their protein levels are mutually dependent in mammalian cells FEBS Letters